Hand-E-Nuke

The is the most powerful explosive implement in. Additionally, it is both the single most valuable item and the most valuable by weight (excluding, of course, weightless items).

The causes 10 million explosive force when it detonates, dealing up to a total of  damage to everything caught inside. Due to the nature of explosions, the actual damage caused to individual objects and creatures will vary considerably depending on environmental factors.

Safe Use
There are several ways to safely detonate a, or at least to greatly increase the chances that you will be safe when detonating it:
 * Use a to fire it across the screen.
 * Make  extra  sure you're going to hit something - it's best to fire toward a segment of wall or a large group of enemies. The grenade launcher's aim isn't perfect and if you don't hit a target, the nuke can fly completely off screen and disappear without detonating at all (this is true for any grenade launched from the ).
 * Use tinkering to mod the grenade to be phase-conjugate. Then, phase out before throwing it. The grenade will phase back in before detonating, and will not harm you because you are still phased.
 * If you don't have the Phasing mutation, you can still do this by cooking a meal that grants phasing.
 * Use the Lay Mine / Set Bomb skill to set the as a bomb.
 * If there are stairs nearby, you can go up or down one level and you will be safe from the explosion. Explosions do not travel up or down stairs.
 * Otherwise, use whatever items or abilities you can to increase your quickness, movement speed, or sprint speed so that you can run for cover before it explodes. Running behind a few layers of wall is usually a good way to avoid most of the damage.

Visual Demo
Here is an example of a explosion.

Damage Extent
The explosion of the can also destroy objects in adjacent zones.

In the demo GIF above, the zone one screen north was also severely damaged: